Akademik Veri Yönetim Sistemi
2nd International Epigenetics Congress, İstanbul, Türkiye, 2 - 03 Eylül 2023, ss.8
Background: Dietary intakes have been shown to impact on gene expression and regulations through epigenetic mechanism. DNA methylation (DNAm) histone modifications and non-coding RNA regulations are aforementioned epigenetic mechanisms. There were studies showing that nutrient intake such as folate and vitamin B12, weight loss intervention, fruit/vegetable consumption, physical activity and stress and sleep control have alternative effect on DNAm. Therefore DNAm is a promising label as displaying of nutrition. Objective: This review aims to discuss the promoter methylation as a fingerprint of health status. Methods: In this review, data were narratively summarized, with respect to the available evidence based on the current literature available on PubMed, Scopus. Results: The relationship between environmental factors and DNAm has been shown. For instance, diets high in saturated- and polyunsaturated-fats could modify methylation of pro-inflammatory genes related to chronic diseases (FTO, IL6, INSR, POMC, ADIPOQ). Moreover, Mediterranean diet has regulatory effect on methylation of genes connected to immunocompetence and inflammation (PPARGC1B, MAPKAPK2, EEF2, COL18A1, IL4I1, LEPR, PLAGL1, IFRD1). In addition, higher regional DNAm at miscellaneous genes (LINC00319) could be more likely to maintain decreased blood pressure in low-fat diet in respond point of view. Conclusions & Discussion: In theoretical approach, the differentiation of promoter methylation is affected right after exposure (nutrition) but before phenotypic features introduced. Since these differentiations are reversible, they are promising to predict cardiovascular disease development and having potential a treatment target. Hence, the promoter epigenetic labels can be reversed by dietary interventions before clinical symptoms appear.
Keywords: promoter, methylation, diet, nutrition, epigenetic