Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer


GÖNENÇ A., HACIŞEVKİ A., Aslan S., Torun M., Simsek B.

EUROPEAN JOURNAL OF INTERNAL MEDICINE, vol.23, no.4, pp.350-354, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1016/j.ejim.2012.02.001
  • Journal Name: EUROPEAN JOURNAL OF INTERNAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.350-354
  • Keywords: DNA damage, Antioxidant enzymes, Gastrointestinal cancer, Antioxidant capacity, LIPID-PEROXIDATION, COLORECTAL-CANCER, NITRIC-OXIDE, SUPEROXIDE-DISMUTASE, BREAST-CANCER, ENZYME-ACTIVITIES, LUNG-CANCER, GLUTATHIONE, STRESS, MECHANISMS
  • Gazi University Affiliated: Yes

Abstract

Background: Highly active intermediates are formed in aerobic metabolism which in turn leads to cellular damage. It is increasingly proposed that free radicals play a key role in human cancer development. The aim of this study was to investigate changes in 8-hydroxy-deoxyguanosine, nitrite+nitrate, total glutathione, total antioxidant capacity levels and superoxide dismutase, catalase, glutathione peroxidase activities in operative patients with gastrointestinal cancer before and after surgery and compare with inoperative patients.