Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer

GÖNENÇ A., HACIŞEVKİ A., Aslan S., Torun M., Simsek B.

EUROPEAN JOURNAL OF INTERNAL MEDICINE, cilt.23, sa.4, ss.350-354, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.ejim.2012.02.001
  • Dergi Adı: EUROPEAN JOURNAL OF INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.350-354
  • Anahtar Kelimeler: DNA damage, Antioxidant enzymes, Gastrointestinal cancer, Antioxidant capacity, LIPID-PEROXIDATION, COLORECTAL-CANCER, NITRIC-OXIDE, SUPEROXIDE-DISMUTASE, BREAST-CANCER, ENZYME-ACTIVITIES, LUNG-CANCER, GLUTATHIONE, STRESS, MECHANISMS
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Highly active intermediates are formed in aerobic metabolism which in turn leads to cellular damage. It is increasingly proposed that free radicals play a key role in human cancer development. The aim of this study was to investigate changes in 8-hydroxy-deoxyguanosine, nitrite+nitrate, total glutathione, total antioxidant capacity levels and superoxide dismutase, catalase, glutathione peroxidase activities in operative patients with gastrointestinal cancer before and after surgery and compare with inoperative patients.