Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer
EUROPEAN JOURNAL OF INTERNAL MEDICINE, cilt.23, sa.4, ss.350-354, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 4
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.ejim.2012.02.001
- Dergi Adı: EUROPEAN JOURNAL OF INTERNAL MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.350-354
- Anahtar Kelimeler: DNA damage, Antioxidant enzymes, Gastrointestinal cancer, Antioxidant capacity, LIPID-PEROXIDATION, COLORECTAL-CANCER, NITRIC-OXIDE, SUPEROXIDE-DISMUTASE, BREAST-CANCER, ENZYME-ACTIVITIES, LUNG-CANCER, GLUTATHIONE, STRESS, MECHANISMS
- Gazi Üniversitesi Adresli: Evet
Özet
Background: Highly active intermediates are formed in aerobic metabolism which in turn leads to cellular damage. It is increasingly proposed that free radicals play a key role in human cancer development. The aim of this study was to investigate changes in 8-hydroxy-deoxyguanosine, nitrite+nitrate, total glutathione, total antioxidant capacity levels and superoxide dismutase, catalase, glutathione peroxidase activities in operative patients with gastrointestinal cancer before and after surgery and compare with inoperative patients.