Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer


GÖNENÇ A. , HACIŞEVKİ A. , Aslan S., Torun M., Simsek B.

EUROPEAN JOURNAL OF INTERNAL MEDICINE, vol.23, no.4, pp.350-354, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1016/j.ejim.2012.02.001
  • Title of Journal : EUROPEAN JOURNAL OF INTERNAL MEDICINE
  • Page Numbers: pp.350-354

Abstract

Background: Highly active intermediates are formed in aerobic metabolism which in turn leads to cellular damage. It is increasingly proposed that free radicals play a key role in human cancer development. The aim of this study was to investigate changes in 8-hydroxy-deoxyguanosine, nitrite+nitrate, total glutathione, total antioxidant capacity levels and superoxide dismutase, catalase, glutathione peroxidase activities in operative patients with gastrointestinal cancer before and after surgery and compare with inoperative patients.