Synthesis, characterization and genotoxicity of platinum(II) complexes with subtituted benzimidazole ligands

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Algul O., Ozcelik B., Abbasoglu U., Gumus F.

TURKISH JOURNAL OF CHEMISTRY, cilt.29, sa.6, ss.607-615, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 6
  • Basım Tarihi: 2005
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.607-615
  • Gazi Üniversitesi Adresli: Evet

Özet

Five Pt(II) complexes with the ligands 2-ethyl-/ or-benzyl-/ or-phenoxymethyl- and 1-methyl-2-hydroxymethyl- and 1-methyl-2-phenyl-benzimidazoles were synthesized and characterized by elemental analysis, and IR and H-1-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained in this study, the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds.