Synthesis, characterization and genotoxicity of platinum(II) complexes with subtituted benzimidazole ligands


Algul O., Ozcelik B., Abbasoglu U., Gumus F.

TURKISH JOURNAL OF CHEMISTRY, vol.29, no.6, pp.607-615, 2005 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 6
  • Publication Date: 2005
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.607-615

Abstract

Five Pt(II) complexes with the ligands 2-ethyl-/ or-benzyl-/ or-phenoxymethyl- and 1-methyl-2-hydroxymethyl- and 1-methyl-2-phenyl-benzimidazoles were synthesized and characterized by elemental analysis, and IR and H-1-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained in this study, the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds.