Triterpenoidal alkaloids from Buxus hyrcana and their enzyme inhibitory, anti-fungal and anti-leishmanial activities

Ata A., Iverson C. D., Kalhari K. S., Akhter S., Betteridge J., Meshkatalsadat M. N., ...Daha Fazla

PHYTOCHEMISTRY, cilt.71, ss.1780-1786, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.phytochem.2010.06.017
  • Dergi Adı: PHYTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1780-1786
  • Anahtar Kelimeler: Buxus hyrcana, Cholinesterase inhibitory activity, Triterpenoidal alkaloids, Anti-microbial activity, STEROIDAL ALKALOIDS, CHEMICAL-CONSTITUENTS, ACETYLCHOLINESTERASE, PRODUCTS
  • Gazi Üniversitesi Adresli: Evet

Özet

From the aerial parts of Buxus hyrcana, three triterpenoidal alkaloids, 17-oxo-3-benzoylbuxadine (1), buxhyrcamine (2), and 31-demethylcyclobuxoviridine (3), along with 16 known compounds, cyclobuxo-viridine (4), N-b-dimethylcyclobuxoviricine (5), E-buxenone (6), Z-buxenone (7), moenjodaramine (8), homomoenjodarmine (9), buxamine A (10), buxamine B (11), 31-hydroxybuxamine B (12), N-20-formylbuxaminol E (13), papillozine C (14), buxmicrophylline F (15), buxrugulosamine (16), cyclobuxophylline 0 (17), spirofornabuxine (18) and arbora-1,9(11)-dien-3-one (19) were isolated. Their structures were elucidated by using NMR spectroscopic methods. All of the compounds exhibited moderate to weak acetylcholinesterase, butyrylcholinesterase and glutathione S-transferase inhibitory activities. Compounds 1-19 also exhibited modest anti-fungal activities against Candida albicans. Compounds 1, 2, 8, 9 and 18 also exhibited weak anti-leishmanial activity. (C) 2010 Elsevier Ltd. All rights reserved.