Upregulation of potential regulatory signaling molecules correlate with androgen receptor splice variants AR-V7 and AR-V567es in prostate cancer metastasis.

Kiliccioglu I., Bilen C. Y., Sozen S., Konac E.

Gene, cilt.772, ss.145377, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 772
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.gene.2020.145377
  • Dergi Adı: Gene
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Artic & Antarctic Regions, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.145377
  • Anahtar Kelimeler: Prostate cancer, Metastatic prostate cancer, Androgen receptor splice variants, Nuclear factor kappa-B, Heat shock protein-27
  • Gazi Üniversitesi Adresli: Evet

Özet

Aim: Androgen receptor splice variants (AR-Vs) produced by alternative splicing of the AR play an important role in the treatment resistance and progression of prostate cancer (PCa). In this study, two most common AR variants and how they associate with the inflammatory response (NF-K beta) and regulatory transcriptional activity (HSP-27) genes were investigated in patients with PCa and metastatic PCa (Met-PCa).