Synthesis of the amide derivatives of 3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3-yl]propanoic acids as potential analgesic compounds

BANOĞLU E., Sukuroglu M. K., Ergun B., BAYTAŞ S., Aypar E., Aark M.

TURKISH JOURNAL OF CHEMISTRY, cilt.31, sa.6, ss.677-687, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 6
  • Basım Tarihi: 2007
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.677-687
  • Anahtar Kelimeler: pyridazine, pyrazole, analgesic, writhing, PYRIDAZINONE DERIVATIVES
  • Gazi Üniversitesi Adresli: Evet

Özet

A series of structurally diverse amide derivatives of 3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3yl]propanoic acids were prepared and tested for their in vivo analgesic activity using an acetic acid induced writhing test. All the test compounds displayed approximately equipotent analgesic activity to aspirin. The results showed that the analgesic activity of 5a, 5f, 5n, and 5o is significantly higher than that of 5d.