The effect of dexketoprofen trometamol on WAG/Rij rats with absence epilepsy (dexketoprofen in absence epilepsy)


Erdil A., Demirsoy M. S. , Çolak S., Duman E., Sümbül O., Aygun H.

Neurological Research, vol.43, no.12, pp.1116-1125, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 12
  • Publication Date: 2021
  • Doi Number: 10.1080/01616412.2021.1952510
  • Journal Name: Neurological Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.1116-1125
  • Keywords: Epileptogenesis, inflammation, absence epilepsy, dexketoprofen, WAG, Rij rats, DEPRESSIVE-LIKE BEHAVIOR, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, 3RD MOLAR SURGERY, ANTIEPILEPTIC DRUGS, ANALGESIC EFFICACY, ANIMAL-MODELS, SEIZURES, LIPOPOLYSACCHARIDE, ANXIETY, EPILEPTOGENESIS
  • Gazi University Affiliated: No

Abstract

© 2021 Informa UK Limited, trading as Taylor & Francis Group.Aim: Epilepsy is one of the most common neurological diseases. Dexketoprofen (DEX) is a nonselective nonsteroidal anti-inflammatory drug that is used as an analgesic. The present study aimed to assess the efficiency of DEX on WAG/Rij rats by electrophysiologically and behaviorally. Material and Methods: Twenty-eight male WAG/Rij rats were used. The effects of acute treatment with DEX (5, 25, and 50 mg/kg, i.p) on absence-like seizures, and related psychiatric comorbidity were assessed. The ECoG recording was taken for 180 min before and after drug injection. After drug injection and EcoG recording, anxiety-depression-like behavior was tested with the open field test for 5 min. Results: The 5 mg/kg DEX significantly reduced the number and duration of SWDs percentage (p < 0.05) between 120 and 180 min, but 25 and 50 mg/kg DEX significantly increased the number and duration of SWDs percentage between 0 and 30 min (p < 0.05), and after 30 min the increase stopped (p > 0.05). And also, the 5 mg/kg DEX decreased the number and duration of SWDs percentage (p < 0.05) for 180 min (p < 0.05), but 25 and 50 mg/kg DEX administration did not alter (p > 0.05). The 5, 25, and 50 mg/kg doses of DEX significantly increased the duration of grooming (p < 0.05) but did not change the number of squares crossed (p > 0.05). Conclusion: Low dose DEX reduced absence-like seizures, but care should be taken when using high doses in absence epilepsy. Also, it may be beneficial for painful diseases accompanied by anxiety-depression.