[I-123] FP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods

Tossici-Bolt L., Dickson J. C. , Sera T., Booij J., Asenbaun-Nan S., Bagnara M. C. , ...More

EJNMMI PHYSICS, vol.4, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4
  • Publication Date: 2017
  • Doi Number: 10.1186/s40658-017-0175-6
  • Title of Journal : EJNMMI PHYSICS


Background: [I-123] FP-CIT is a well-established radiotracer for the diagnosis of dopaminergic degenerative disorders. The European Normal Control Database of DaTSCAN (ENC-DAT) of healthy controls has provided age and gender-specific reference values for the [I-123] FP-CIT specific binding ratio (SBR) under optimised protocols for image acquisition and processing. Simpler reconstruction methods, however, are in use in many hospitals, often without implementation of attenuation and scatter corrections. This study investigates the impact on the reference values of simpler approaches using two quantifications methods, BRASS and Southampton, and explores the performance of the striatal phantom calibration in their harmonisation.