Determination of the effects of bone marrow derived mesenchymal stem cells and ovarian stromal stem cells on follicular maturation in cyclophosphamide induced ovarian failure in rats

BEŞİKCİOĞLU, HÜSEYİN; SARIBAŞ, GÜLİSTAN; Ozogul, Candan; Tiryaki, Meral; Kilic, Sevtap; Pinarli, Ferda; GÜLBAHAR, ÖZLEM

doi:10.1016/j.tjog.2018.11.010

Determination of the effects of bone marrow derived mesenchymal stem cells and ovarian stromal stem cells on follicular maturation in cyclophosphamide induced ovarian failure in rats

BEŞİKCİOĞLU H. E. , SARIBAŞ G. S. , Ozogul C., Tiryaki M., Kilic S., Pinarli F. A. , ...More

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, vol.58, no.1, pp.53-59, 2019 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 58 Issue: 1
Publication Date: 2019
Doi Number: 10.1016/j.tjog.2018.11.010
Title of Journal : TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
Page Numbers: pp.53-59
Keywords: Cyclophosphamide, Ovary, Ovarian follicle, Stem cells, GAP-JUNCTIONS, EXPRESSION, COMMUNICATION, FERTILITY, CANCER, AGENTS, CYCLE

Abstract

Objective: Chemotherapy causes depletion of primordial follicles that leads to premature ovarian failure in female cancer survivals. We investigated the effect of bone marrow derived mesenchymal (BMMSCs) and ovarian stromal stem cells (OSSCs) on follicle maturation in chemotherapy induced ovarian failure.