Akademik Veri Yönetim Sistemi
CANCER BIOMARKERS, cilt.42, sa.3, ss.1-8, 2025 (SCI-Expanded)
Abstract
Background: As the role of physical activity in breast cancer management gains increasing recognition, understanding
the effects of aerobic exercise on patients’ quality of life and biological markers has emerged as a critical area of research
to inform clinical practices and improve patient outcomes.
Objective: This study aims to investigate the impact of low-intensity resistance exercise training on serum tumor bio-
markers and quality of life in women with breast cancer, providing evidence for its potential role as an adjunct therapy in
improving clinical outcomes and patient well-being.
Methods: This study was carried out on 70 women between the ages of 18 and 65, who were included in the study while
receiving chemotherapy treatment. The subject was divided into low-intensity resistance exercise (Group I) and control
(Group II). Demographic characteristics, quality of life, and serum tumor biomarkers were evaluated. Participants in
group I underwent a 12-week exercise programme of low-intensity resistance exercises three times a week (three meta-
bolic equivalents, approximately 30 min/session).
Results: The quality of life has been found to be significantly higher in the low-intensity resistance exercise group (p <
0.05). The serum tumor biomarker levels of CEA, CA15-3, and CA19-9 decreased across all participants. However, the
reduction in serum tumor biomarker levels was found to be more pronounced in Group 1 (p < 0.05).
Conclusions: Low-intensity resistance exercise has demonstrated a positive effect on the quality of life in women with
breast cancer. Within the framework of oncological rehabilitation, aerobic exercise regimens may be preferred due to
their role in promoting improvements in serum tumor biomarker levels and contributing to enhanced quality of life