Evaluation of tenoxicam on prevention of arachnoiditis in rat laminectomy model

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Cemil B., KURT G., Aydin C., AKYÜREK N., Erdogan B., Ceviker N.

EUROPEAN SPINE JOURNAL, cilt.20, sa.8, ss.1255-1258, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00586-011-1706-9
  • Dergi Adı: EUROPEAN SPINE JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1255-1258
  • Anahtar Kelimeler: Arachnoiditis, Laminectomy, Non-steroidal anti-inflammatory drugs, Tenoxicam, ADHESIVE ARACHNOIDITIS, SPINAL ARACHNOIDITIS, LUMBAR SPINE, BRAIN
  • Gazi Üniversitesi Adresli: Evet

Özet

Post laminectomy arachnoiditis has been shown by experiments with rats and post operative radiological imaging in humans. The purpose of this experimental study was to determine the efficacy of tenoxicam in preventing arachnoiditis in rats. Twenty-four Wistar rats were divided into two groups, and L3 laminectomy was performed. In the tenoxicam group, 0.5 mg/kg tenoxicam was applied intraperitoneally. Normal saline was applied intraperitoneally in the control group. Later, the rats were killed at weeks 3 and 6, and the laminectomy sites were evaluated pathologically for arachnoiditis. The results showed that 6 weeks after surgery, the tenoxicam group showed lowest arachnoiditis grades. However, statistically significant difference was not found in arachnoiditis between the control group and the tenoxicam group. Based on these findings it is concluded that application of the tenoxicam after lumbar laminectomy did not effectively reduce arachnoiditis. Performing the most effective surgical technique without damage around tissue in a small surgical wound and having meticulous hemostasis in surgery seem to be the key for preventing arachnoiditis effectively.