EFFECT OF THE SULFONYLUREA GLYBURIDE ON SUPEROXIDE-DISMUTASE ACTIVITY IN ALLOXAN-INDUCED DIABETIC RAT HEPATOCYTES


ALTAN N., ONGUN C., HASANOGLU E., ENGIN A., TUNCER C., SINDEL S.

DIABETES RESEARCH AND CLINICAL PRACTICE, cilt.22, ss.95-98, 1994 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 22
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0168-8227(94)90041-8
  • Dergi Adı: DIABETES RESEARCH AND CLINICAL PRACTICE
  • Sayfa Sayıları: ss.95-98

Özet

In the present study we administrated glyburide (glibenclamide) to type 2 (NIDDM) diabetic rats and determined the effect of such treatment on liver superoxide dismutase (SOD) activity. Hepatic SOD activity was significantly reduced in diabetic animals. Glyburide treatment of diabetic rats for 4 weeks corrected the changes observed in diabetic liver. In addition, blood glucose levels of untreated diabetic rats decreased following glyburide treatment. Administration of glyburide to diabetic rats reversed the diabetes-induced changes, suggesting that glyburide may directly increase liver SOD enzyme activity.