Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction


HAN S. , BAL N. B. , SADİ G., USANMAZ S. E. , Tuglu M. M. , ULUDAĞ M. O. , ...Daha Fazla

VASCULAR PHARMACOLOGY, cilt.113, ss.38-46, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 113
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.vph.2018.11.004
  • Dergi Adı: VASCULAR PHARMACOLOGY
  • Sayfa Sayıları: ss.38-46

Özet

Hypertension has complex vascular pathogenesis and therefore the molecular etiology remains poorly elucidated. Endoplasmic reticulum stress (ERS), which is a condition of the unfolded/misfolded protein accumulation in the endoplasmic reticulum, has been defined as a potential target for cardiovascular disease. In the present study, the effects of ERS inhibition on hypertension-induced alterations in the vessels were investigated.