Insulin-like growth factor-1 receptor expression in pediatric tumors: a comparative immunohistochemical study


Karakuş R., Karakus E., Emir S., Kacar A., Ozyoruk D.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.48, no.2, pp.419-423, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.3906/sag-1801-233
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.419-423
  • Keywords: Insulin-like growth factor-1 receptor, endodermal sinus tumor, neuroblastoma, Wilms tumor, rhabdomyosarcoma, CELL LUNG-CANCER, MONOCLONAL-ANTIBODY, PROTEIN EXPRESSION, COPY NUMBER, RHABDOMYOSARCOMA, OSTEOSARCOMA, SARCOMAS, PATHWAY, IGF-1R, GENE
  • Gazi University Affiliated: Yes

Abstract

Background/aim: Insulin-like growth factor-1 receptor (IGF-1R) is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. It is differentially expressed in various types of tumors. We aimed to determine the expression of IGF-1R in different pediatric tumors and to shed light on possible new indications of anti-IGF-1R treatment approaches.