Arpacı A.H., Çalışkan H., Güneş E. Işık B. Recurrent Ketamine Exposure Impaired Spatial Memory and Increased Stretched-attend Posture in Juvenile Male Rat" Oral Presentation (Paper ID:929)

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Arpacı A. H., Çalışkan H., Güneş E., Işık B.

Arpacı A.H., Çalışkan H., Güneş E. Işık B. Recurrent Ketamine Exposure Impaired Spatial Memory and Increased Stretched-attInternational Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022), Ankara, Türkiye, 23 - 25 Kasım 2022, sa.929, ss.338, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.338
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Gazi Üniversitesi Adresli: Evet

Özet

Ketamine is commonly used anesthetic agents in pediatric population due to some clinical advantages. But contradictory results have been reported in the literature regarding negative or positive effects on developing brain. The present study aimed to investigate the short-term effect of recurrent and different doses ketamine exposure on spatial memory, anxietylike behaviors and locomotor activity in juvenile rats.32 Wistar Albino male rats were randomised into four groups [(n=8), Control, 5, 20 and 50 mg/kg ketamine group]. Ketamine was administered 3 days, 3 doses a day by 3 hours intervals intraperitoneally (i.p). After 10 days, behavior parameters were evaluated by an Open Field Test, Elevated Plus Maze Test and Light Dark Box Test. Statistical analysis was performed One- Way Anova, and followed by Tukey Tests. Significance value was admitted p<0.05. There was no difference between groups in total rearing number and total distance travelled as locomotor activity. Transfer latency time incerased significantly in 50 mg/kg ketamine group vs control group (p < 0.001). Anxiety- like behavior decreased in only 20 mg/kg Ketamine group particularly light dark box parameters (p<0.05). Stretched attend posture increased significantly in 50 mg/kg group (p<0.01). Unssuported rearing behavior decreased in 5 and 50 mg/ketamine group vs control (p<0.05). Our study revealed that 50 mg/kg ketamine had shown detrimental effect on effect on spatial memory, exploratory behavior and incresed anxiety like behaviors such as streched attand posture. Despite of the 50 mg/kg group, 20 mg/kg had anxiolytic effect on juvenile rats. Doses of the ketamine must be considered in pediatric group whose are critical for neurogenesis. Further behavioral and histopathological researches are needed to elucidate the dose effects relation in pediatric groups for ketamine. Keyword: Ketamine, Rat behaviours, Spatial memory