Effects of soluble fiber on matrix metal loproteinase-2 activity and heating of colon anastomosis in rats given radiotherapy

Kerem, Mustafa; Bedirli, Abdulkadir; Karahacioglu, Eray; Pasaoglu, HATİCE; Sahin, Onder; Bayraktar, Nilufer; Yilmaz, Tonguc; Sakrak, Omer; Goksel, Fatih; Oguz, Mehmet

doi:10.1016/j.clnu.2006.01.028

Effects of soluble fiber on matrix metal loproteinase-2 activity and heating of colon anastomosis in rats given radiotherapy

Kerem M., Bedirli A., Karahacioglu E., Pasaoglu H. , Sahin O., Bayraktar N., ...More

CLINICAL NUTRITION, vol.25, no.4, pp.661-670, 2006 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 25 Issue: 4
Publication Date: 2006
Doi Number: 10.1016/j.clnu.2006.01.028
Title of Journal : CLINICAL NUTRITION
Page Numbers: pp.661-670
Keywords: soluble fiber, short-chain fatty acid, colon anastomosis, radiotherapy, matrix metalloproteinase-2, CHAIN FATTY-ACIDS, EXPERIMENTAL INTESTINAL ANASTOMOSES, EPITHELIAL-CELL PROLIFERATION, TOTAL MESORECTAL EXCISION, PRIMARY RECTAL-CANCER, HYDROLYZED GUAR GUM, PREOPERATIVE RADIOTHERAPY, COLLAGENOLYTIC ACTIVITY, FERMENTABLE FIBER, RANDOMIZED-TRIAL

Abstract

Background and aims: Soluble fiber is fermented by colonic microflora yielding short-chain fatty acids (SCFAs) in the colon. We aimed to investigate the effect of oral administration of soluble fiber on heating of anastomosis and matrix metalloproteinase-2 activity in radiotherapy received colonic anastomosis.