Synthesis of new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives and their analgesic and anti-inflammatory properties

Gulcan H., Unlu S., BANOĞLU E., Sahin M., Kupeli E., Yesilada E.

TURKISH JOURNAL OF CHEMISTRY, cilt.27, sa.4, ss.467-476, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2003
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.467-476
  • Anahtar Kelimeler: 2-oxo-3H-benzoxazole, butanamide, analgesic, anti-inflammatory, COX-1, COX-2, ANTICONVULSANT ACTIVITY, 2(3H)-BENZOXAZOLONE, SELECTIVITY, INHIBITION
  • Gazi Üniversitesi Adresli: Evet

Özet

In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tested animals. Their structures were elucidated by their IR, H-1-NMR and elemental analysis. All of the compounds exhibited high analgesic and anti-inflammatory activities. None of the compounds except compound 2g caused gastric lesions or bleeding in tested animals.