Synthesis of new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives and their analgesic and anti-inflammatory properties


Gulcan H., Unlu S., BANOĞLU E. , Sahin M., Kupeli E., Yesilada E.

TURKISH JOURNAL OF CHEMISTRY, vol.27, no.4, pp.467-476, 2003 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2003
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.467-476

Abstract

In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tested animals. Their structures were elucidated by their IR, H-1-NMR and elemental analysis. All of the compounds exhibited high analgesic and anti-inflammatory activities. None of the compounds except compound 2g caused gastric lesions or bleeding in tested animals.