Synthesis of new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives and their analgesic and anti-inflammatory properties


Gulcan H., Unlu S., BANOĞLU E., Sahin M., Kupeli E., Yesilada E.

TURKISH JOURNAL OF CHEMISTRY, vol.27, no.4, pp.467-476, 2003 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2003
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.467-476
  • Keywords: 2-oxo-3H-benzoxazole, butanamide, analgesic, anti-inflammatory, COX-1, COX-2, ANTICONVULSANT ACTIVITY, 2(3H)-BENZOXAZOLONE, SELECTIVITY, INHIBITION

Abstract

In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tested animals. Their structures were elucidated by their IR, H-1-NMR and elemental analysis. All of the compounds exhibited high analgesic and anti-inflammatory activities. None of the compounds except compound 2g caused gastric lesions or bleeding in tested animals.