Condensed 1,4-dihydropyridines with various esters and their calcium channel antagonist activities


Bulbul B., Ozturk G. S. , Vural M., ŞİMŞEK R., Sarioglu Y., Linden A., ...More

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.44, no.5, pp.2052-2058, 2009 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 2009
  • Doi Number: 10.1016/j.ejmech.2008.10.008
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.2052-2058
  • Keywords: Hexahydroquinoline, Furoquinoline, Calcium antagonistic activity, Biotransformation, NITRIC-OXIDE, SMOOTH-MUSCLE, PHARMACOLOGICAL-ACTIVITIES, IN-VITRO, DERIVATIVES, HEXAHYDROQUINOLINONES, MODULATORS, CELLS

Abstract

New alkyl 2,6,6-(2,7,7)-trimethyl-4-(2-fluoro-3-chloro-5-trifluoromethylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and 9-(3-chloro-2-fluoro-5-trifluoromethylphenyl)-6,6(7,7)-dimethyl-6,7-dihydrofuro[3,4-b]quinoline-1,8-diones have been synthesised and their calcium antagonistic activities on isolated rabbit sigmoid colon have been investigated and compared with Nifedipine. The investigation examined the influence of ester groups in the 3-position of the HHQ ring and the 2-methoxyethyl analogs were found to be the most active derivatives. (C) 2008 Elsevier Masson SAS. All rights reserved.