Akademik Veri Yönetim Sistemi
MEDICAL PRINCIPLES AND PRACTICE, cilt.31, sa.6, ss.548-554, 2022 (SCI-Expanded)
Background: Resolvin D1 (RvD1) can play a determining role in inflammatory cell migration and reduce the expression of inflammatory cytokines to enhance cardioprotection. The aim of this study was to compare serum RvD1 levels in patients with ST-elevation myocardial infarction (STEMI) and in individuals with normal coronary arteries (NCA); and to evaluate the association between serum RvD1 levels and prognostic markers of STEMI.Methods: A total of 140 individuals, consisting of 88 patients diagnosed with the indication of STEMI and 52 healthy individuals with NCA, were included. Results: Regression analysis revealed that the RvD1 levels were independently associated with the STEMI. While RvD1 levels were negatively correlated with high-sensitivity C-reactive protein, pro-brain natriuretic peptide, peak troponin, and the Thrombolysis in Myocardial Infarction (TIMI) thrombus grade, they were positively correlated with left ventricular ejection fraction. A RvD1 cut-off value 5.07 (ng/ml) was effective in predicting STEMI with a sensitivity of 79.5% and specificity of 96.2%. Conclusion: Serum Resolvin D1 levels were detected to be lower in the group with STEMI compared to the control group. Admission RvD1 levels were associated with poor prognostic markers of STEMI.