Sex-Related Influences in Migraine

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Pavlovic J. M., Akcali D. T., Bolay H. B., Bernstein C., Maleki N.

JOURNAL OF NEUROSCIENCE RESEARCH, vol.95, pp.587-593, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 95
  • Publication Date: 2017
  • Doi Number: 10.1002/jnr.23903
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.587-593
  • Keywords: hormones, estrogen, menstrual migraine, menopause, cortical spreading depression, trigeminal pathway, neuroimaging, CORTICAL SPREADING DEPRESSION, FREELY MOVING RATS, MENSTRUAL-CYCLE, UNITED-STATES, SOCIODEMOGRAPHIC FACTORS, HORMONAL CYCLE, HUMAN BRAIN, HEADACHE, PREVALENCE, PAIN
  • Gazi University Affiliated: Yes


Migraine is a common neurological disorder with significantly higher incidence and prevalence in women than men. The presentation of the disease in women is modulated by changes in sex hormones from adolescence to pregnancy and menopause. Yet, the effect of sex influences has often been neglected in both basic and clinical and in clinical management of the disease. In this review, evidence from epidemiological, clinical, animal, and neuroimaging studies on the significance of the sex-related influences in migraine is presented, and the unmet needs in each area are discussed. (C) 2016 Wiley Periodicals, Inc.