The fabrication of a highly sensitive electrochemical sensor based on AuNPs@graphene nanocomposite: Application to the determination of antidepressant vortioxetine

Ates A. K., ER E., ÇELİKKAN H., ERK N.

MICROCHEMICAL JOURNAL, vol.148, pp.306-312, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 148
  • Publication Date: 2019
  • Doi Number: 10.1016/j.microc.2019.04.082
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.306-312
  • Keywords: Graphene, Gold nanoparticles, Electrochemical sensor, Adsorptive stripping voltammetry, Vortioxetine, Determination, GOLD NANOPARTICLES, DOUBLE-BLIND, RAT PLASMA, OXIDE, PERFORMANCE, METABOLITE, METAL
  • Gazi University Affiliated: Yes


This is the first report to development of a new generation and highly sensitive electrochemical sensing platform based on gold nanoparticles/graphene/(AuNPs@GRP) nanocomposite for the detection of vortioxetine (VOR). The electrochemical behavior of VOR has been investigated through adsorptive stripping differential pulse voltammetry (AdsDPV) on the proposed electrochemical sensor (AuNPs@GRP/GCE). The structural and morphological characterizations of fabricated AuNPs@GRP composite were performed by x-ray diffraction (XRD) and transmission electron microscopy (TEM) methods. A well-defined and irreversible oxidation peak at 972 mV was observed on the surface of AuNPs@GRP/GCE. The proposed electrochemical sensor exhibited outstanding electrocatalytic activity towards the electroxidation of VOR. Under the optimized conditions, the voltammetric response was linearly proportional to VOR concentration at two working range of 0.1-1.0 and 1.0-6.0 mu M with a low detection limit of 50.0 nM. The developed sensor was successfully carried out for reliable determination of VOR in pharmaceutical sample with satisfying recovery results. AuNPs@GRP/GCE could be utilized as a simple, inexpensive and reliable sensing platform for the routine analysis of VOR as an antidepressant drug in pharmaceutical samples.