Tetraspanins CD9 and CD151, epidermal growth factor receptor and cyclooxygenase-2 expression predict malignant progression in oral epithelial dysplasia

Nankivell, P.; Williams, H.; Mcconkey, C.; Webster, K.; High, A.; Maclennan, K.; Senguven, BURCU; Rabbitts, P.; Mehanna, H.

doi:10.1038/bjc.2013.600

Tetraspanins CD9 and CD151, epidermal growth factor receptor and cyclooxygenase-2 expression predict malignant progression in oral epithelial dysplasia

Atıf İçin Kopyala

Nankivell P., Williams H., Mcconkey C., Webster K., High A., Maclennan K., ...Daha Fazla

BRITISH JOURNAL OF CANCER, cilt.109, sa.11, ss.2864-2874, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 109 Sayı: 11
Basım Tarihi: 2013
Doi Numarası: 10.1038/bjc.2013.600
Dergi Adı: BRITISH JOURNAL OF CANCER
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2864-2874
Anahtar Kelimeler: oral dysplasia, tetraspanin, biomarker, prognostic, SQUAMOUS-CELL CARCINOMA, DISEASE-FREE SURVIVAL, METASTASIS SUPPRESSOR, GENE-EXPRESSION, FOLLOW-UP, RETROSPECTIVE COHORT, PROTEIN EXPRESSION, HIGH PREVALENCE, EGF RECEPTOR, TGF-ALPHA
Gazi Üniversitesi Adresli: Evet

Özet

Background: Prognostic biomarkers aim to improve on the current inadequate method of histological assessment to identify patients with oral epithelial dysplasia at greatest risk of malignant transformation. We aimed to assess the prognostic ability of six protein biomarkers linked to the epidermal growth factor receptor (EGFR) pathway, including three tetraspanins, in a large multicentre oral dysplasia cohort.