Tetraspanins CD9 and CD151, epidermal growth factor receptor and cyclooxygenase-2 expression predict malignant progression in oral epithelial dysplasia

Nankivell, P.; Williams, H.; Mcconkey, C.; Webster, K.; High, A.; Maclennan, K.; Senguven, BURCU; Rabbitts, P.; Mehanna, H.

doi:10.1038/bjc.2013.600

Tetraspanins CD9 and CD151, epidermal growth factor receptor and cyclooxygenase-2 expression predict malignant progression in oral epithelial dysplasia

Copy For Citation

Nankivell P., Williams H., Mcconkey C., Webster K., High A., Maclennan K., ...More

BRITISH JOURNAL OF CANCER, vol.109, no.11, pp.2864-2874, 2013 (SCI-Expanded)

Publication Type: Article / Article
Volume: 109 Issue: 11
Publication Date: 2013
Doi Number: 10.1038/bjc.2013.600
Journal Name: BRITISH JOURNAL OF CANCER
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2864-2874
Keywords: oral dysplasia, tetraspanin, biomarker, prognostic, SQUAMOUS-CELL CARCINOMA, DISEASE-FREE SURVIVAL, METASTASIS SUPPRESSOR, GENE-EXPRESSION, FOLLOW-UP, RETROSPECTIVE COHORT, PROTEIN EXPRESSION, HIGH PREVALENCE, EGF RECEPTOR, TGF-ALPHA
Gazi University Affiliated: Yes

Abstract

Background: Prognostic biomarkers aim to improve on the current inadequate method of histological assessment to identify patients with oral epithelial dysplasia at greatest risk of malignant transformation. We aimed to assess the prognostic ability of six protein biomarkers linked to the epidermal growth factor receptor (EGFR) pathway, including three tetraspanins, in a large multicentre oral dysplasia cohort.