Tetraspanins CD9 and CD151, epidermal growth factor receptor and cyclooxygenase-2 expression predict malignant progression in oral epithelial dysplasia


Nankivell P., Williams H., Mcconkey C., Webster K., High A., Maclennan K., ...More

BRITISH JOURNAL OF CANCER, vol.109, no.11, pp.2864-2874, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 109 Issue: 11
  • Publication Date: 2013
  • Doi Number: 10.1038/bjc.2013.600
  • Journal Name: BRITISH JOURNAL OF CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2864-2874
  • Keywords: oral dysplasia, tetraspanin, biomarker, prognostic, SQUAMOUS-CELL CARCINOMA, DISEASE-FREE SURVIVAL, METASTASIS SUPPRESSOR, GENE-EXPRESSION, FOLLOW-UP, RETROSPECTIVE COHORT, PROTEIN EXPRESSION, HIGH PREVALENCE, EGF RECEPTOR, TGF-ALPHA
  • Gazi University Affiliated: Yes

Abstract

Background: Prognostic biomarkers aim to improve on the current inadequate method of histological assessment to identify patients with oral epithelial dysplasia at greatest risk of malignant transformation. We aimed to assess the prognostic ability of six protein biomarkers linked to the epidermal growth factor receptor (EGFR) pathway, including three tetraspanins, in a large multicentre oral dysplasia cohort.