Effects of protamine on nitric oxide level in the pulmonary circulation

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Kalaycioglu S., Sinci V., Erbas D.

JAPANESE HEART JOURNAL, vol.40, no.3, pp.335-338, 1999 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 1999
  • Doi Number: 10.1536/jhj.40.335
  • Title of Journal : JAPANESE HEART JOURNAL
  • Page Numbers: pp.335-338


Protamine reversal of heparin anticoagulation often causes systemic hypotension by releasing nitric oxide (NO) from vascular endothelium. We investigated the hypothesis that protamine prevents severe pulmonary vasoconstriction by increasing NO.