Effects of protamine on nitric oxide level in the pulmonary circulation

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Kalaycioglu S., Sinci V., Erbas D.

JAPANESE HEART JOURNAL, cilt.40, sa.3, ss.335-338, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Konu: 3
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1536/jhj.40.335
  • Dergi Adı: JAPANESE HEART JOURNAL
  • Sayfa Sayıları: ss.335-338

Özet

Protamine reversal of heparin anticoagulation often causes systemic hypotension by releasing nitric oxide (NO) from vascular endothelium. We investigated the hypothesis that protamine prevents severe pulmonary vasoconstriction by increasing NO.