The role of lipid peroxidation in the genesis of vasospasm secondary to subarachnoid hemorrhage.

Caner H., Oruçkaptan H., BELEN H. B. , Kilinç K., Senaati S., Benli K., ...Daha Fazla

The Kobe journal of medical sciences, cilt.37, sa.1, ss.13-20, 1991 (Diğer Kurumların Hakemli Dergileri) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Konu: 1
  • Basım Tarihi: 1991
  • Dergi Adı: The Kobe journal of medical sciences
  • Sayfa Sayıları: ss.13-20


The aim of this study is to find out the possible trigger role of lipid peroxidation in vasospasm. Haemoglobin-free washed erythrocyte membranes (erythrocyte ghost) corresponding to 2.5 mg membrane protein was mixed with 0.5 umol NADPH 3 umol ADP, 4 umol ferrous sulphate and injected into the cisterna magna of cats to stimulate lipid peroxidation in vivo (Group 1). The second group was injected lml/kg whole blood and the control group 1 ml/kg saline. Angiographic studies revealed significant vasospasm in five cats in group 1. Severe vasospasm was seen in six cats in group 2. A significant increase in lipid peroxidation was observed in groups 1 and 2, compared to the control group. These results may suggest that free radical products may play an important role in the complex genesis of vasospasm in subarachnoid haemorrhage.