Recent Developments in the Probiotics as Live Biotherapeutic Products (LBPs) as Modulators of Gut Brain Axis Related Neurological Conditions


Ağagündüz D., Gencer Bingöl F., Çelik E., Cemali Ö., Özenir Ç., Özoğul F., ...More

JOURNAL OF TRANSLATIONAL MEDICINE, vol.20, pp.460-486, 2022 (SCI-Expanded)

  • Publication Type: Article / Review
  • Volume: 20
  • Publication Date: 2022
  • Journal Name: JOURNAL OF TRANSLATIONAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.460-486
  • Gazi University Affiliated: Yes

Abstract

Probiotics have been defined as “living microorganisms that create health benefits in
the host when taken in sufficient amounts. Recent developments in the understanding
of the relationship between the microbiom and its host have shown evidence about the
promising potential of probiotics to improve certain health problems. However, today,
there are some confusions about traditional and new generation foods containing
probiotics, naming and classifications of them in scientific studies and also their
marketing. To clarify this confusion, the Food and Drug Administration (FDA) declared
that it has made a new category definition called "live biotherapeutic products" (LBPs).
Accordingly, the FDA has designated LBPs as “ a biological product that: i)contains live
organisms, such as bacteria; ii)is applicable to the prevention, treatment, or cure of a
disease/condition of human beings; and iii) is not a vaccine ”. The accumulated
literature focused on LBPs to determine effective strains in health and disease, and
often focused on obesity, diabetes, and certain diseases like inflammatory bowel
disease (IBD).However, microbiome also play an important role in the pathogenesis of
diseases that age day by day in the modern world via gut-brain axis. Herein, we
discuss the novel roles of LBPs in some gut-brain axis related conditions in the light of
recent studies. This article may be of interest to a broad readership including those
interested in probiotics as LBPs, their health effects and safety, also gut-brain axis