© 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Acromegaly is a pituitary disease characterized by excess growth hormone (GH) secretion in adults which results in several comorbidities and increased mortality. Studies suggest an increased prevalence of both benign and malignant tumors including thyroid nodules, breast diseases and colon polyps in acromegaly. The risk of gallbladder polyps also seems to be increased in acromegaly. Coexistence of thyroid nodules, colon polyps and gallbladder polyps in acromegaly remains uninvestigated. In this study we aimed to investigate the risk factors for the development of thyroid nodules, colon polyps and gallbladder polyps and we aimed to see whether the presence of thyroid nodules is associated with colon polyps or gallbladder polyps in patients with acromegaly. Thirty eight acromegaly patients who are being followed up in the outpatient clinics of Endocrinology and Metabolism in a tertiary care center were involved in the study. Thyroid ultrasonography (US) was performed by the same experienced observer. Abdominal and hepatobiliary ultrasonography reports and colonoscopy reports of all patients with acromegaly were analyzed retrospectively. The present study showed that the presence of thyroid nodules, colon polyps and gall bladder polyps in acromegaly does not depend on one another. In our study, we found that the presence of thyroid nodules, colon polyps and gallbladder polyps in acromegaly were not linked to each other. In other words, the presence of one or both of these comorbidities in a patient was not found to be associated with the others. When clinically indicated, we recommend that each patient with acromegaly be evaluated separately for thyroid nodules, colon polyps, and gallbladder polyps.