Thermodynamics of Molecular Recognitions between Antineoplastic Drug Taxol and Phosphatidylcholine


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Suleymanoglu E.

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, vol.53, no.6, pp.1351-1358, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1590/s1516-89132010000600011
  • Title of Journal : BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
  • Page Numbers: pp.1351-1358

Abstract

The aim of this study was to study the basic features of Taxol recognition with phospholipids by applying the thermodynamic and spectroscopic measurements. The obtained information could be used further for deductions on its precise cellular and pharmacological mechanisms of action, on improvements of its solubility properties by phospholipids, as well as for designing the novel lipidic carriers for drug delivery.