Serological evaluation of Anti-CCP, ANCA and ANA autoantibodies in patients with psoriasis vulgaris and psoriatic arthritis Psöriazis vulgaris ve psöriatik artritli hastalarda Anti-CCP, ANCA ve ANA otoantikorlari{dotless}n serolojik deǧerlendirilmesi


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ATAK YÜCEL A., Sönmez C., Bulur I., Kaşkari D., GÖĞÜŞ F. N. , Gürer M. A.

Turkiye Klinikleri Journal of Medical Sciences, vol.34, no.1, pp.40-46, 2014 (Scopus) identifier

Abstract

Objective: Psoriasis is a chronic, inflammatory and hyperproliferative immune-mediated skin disorder. Psoriatic arthritis is an important comorbidity observed in patients with psoriasis. We aimed to evaluate the importance of some autoantibodies and anti-cyclic citrullinated peptide (-CCP) antibodies in patients with psoriasis vulgaris (PsV) and psoriatic arthritis (PsA), and to contribute to the immunopathogenesis of psoriasis. Material and Methods: Forty four PsV and 45 PsA patients, and 32 healthy volunteers were included in the study. Peripheral venous blood samples were collected from patients and healthy volunteers. In serum samples, Anti-CCP antibodies were studied semi-quantitatively, anti-neutrophil cytoplasmic antibody (ANCA) profiles quantitatively with ELISA method, and antinuclear antibody (ANA) profiles were studied quantitatively by immunoblotting. Results: Totally 8 (8.9%) patients (2 PsA and 6 PsV) were anti-CCP positive. ANCA positivity was not detected in any of our PsV or PsA patients. A 43-year-old woman with PsA was AMA-M2(+), anti-Ro52(++), anti-nucleosome(+), anti-ds DNA(+). A 38-year-old man with PsV had suspicious anti-nRNP/-Sm positivity (in gray zone); a 33-year-old woman with PsV had anti-SS-A positivity. Conclusion: In our study, patients with PsA had less frequent anti-CCP positivity compared to the present data in the literature. ANCA positivity was not detected in any of our patients. ANA profile antibodies were detected only in three patients. Consequently, it is thought that larger scale, multicentered studies are needed in order to enlighten the role of anti-CCP antibodies and other autoantibodies in the immunopathogenesis of psoariasis and psoriatic arthritis. © 2014 by Türkiye Klinikleri.