Bolus fentanyl coadministered with target-controlled infusion of propofol for oocyte retrieval

COŞKUN D., Gunaydin B., Tuna A. T., Celebi H., Kaya K., ERDEM A.

Journal of Reproductive Medicine, cilt.62, sa.6, ss.641-646, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 6
  • Basım Tarihi: 2017
  • Dergi Adı: Journal of Reproductive Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.641-646
  • Anahtar Kelimeler: Adjuvants, Analgesics, Anesthesia, Anesthetics, Assisted reproductive techniques, Fentanyl, Intravenous, Narcotics, Oocyte retrieval, Opioid, Propofol, Target controlled infusion
  • Gazi Üniversitesi Adresli: Evet

Özet

© Journal of Reproductive Medicine®, Inc.OBJECTIVE: To investigate whether administration of 1 or 1.5 μg/kg of fentanyl before onset of targetcontrolled infusion (TCI) of propofol would be an effective and satisfactory analgesic regimen when hemodynamic parameters, pain, sedation, and recovery scores are compared during transvaginal ultrasoundguided oocyte retrieval. STUDY DESIGN: Forty women were scheduled for oocyte retrieval in the present randomized prospective study. Following standard monitorization, patients were randomly allocated to receive either intravenous (IV) bolus fentanyl 1 μg/kg (Group I, n=20) or 1.5 μg/kg (Group II, n=20). Afterwards, TCI propofol at effect site concentration (Ce) 1.5 μg/mL was started and then maintained by adjusting propofol dose due to pain intensity according to numeric rating scale. Hemodynamic variables and sedation scores were recorded every 5 minutes throughout the procedure. RESULTS: Demographic properties and duration of anesthesia and procedure were comparable between the groups. The number of patients requiring dose adjustment was similar between the groups (25% and 30% in groups I and II, respectively). CONCLUSION: We demonstrated that IV bolus administration of fentanyl, either 1 or 1.5 μg/kg with TCI of propofol at Ce 1.5 μg/mL, provided similarly satisfactory conscious sedation and analgesia without changing hemodynamics, recovery profile, and side effects during oocyte retrieval.