The postoperative radiotherapy results of patients with primitive neuroectodermal tumors in childhood

Bora H., Erpolat O. P., Oguz A., Karadeniz C., Karahacioglu E., Akmansu M.

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, cilt.18, sa.1, ss.22-31, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2008
  • Dergi Adı: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.22-31
  • Anahtar Kelimeler: primitive neuroectodermal tumors, medulloblastoma, radiotherapy, overall survival, prognostic factors, CHILDRENS CANCER GROUP, PROSPECTIVE RANDOMIZED TRIAL, PEDIATRIC-ONCOLOGY SIOP, PROGNOSTIC-FACTORS, INTERNATIONAL-SOCIETY, ADJUVANT CHEMOTHERAPY, RADIATION-THERAPY, POSTERIOR-FOSSA, MEDULLOBLASTOMA, EXPERIENCE
  • Gazi Üniversitesi Adresli: Evet

Özet

The primitive neuroectodermal tumors are the second common malignancies among the childhood brain tumors. Theit prognosis are quite variable and the multidisciplinary treatment approach is required. The purpose of our study is to evaluate the factors that can affect overall survival. After the surgery, seventeen patients have received the radiotherapy (median 34.2 Gy to craniospinal region and median 54 Gy to posterior fossa at a 1.5-1.8 Gy daily fractionation dose) and the chemotherapy. The average preoperative tumor volume was 41.5 cm.'. Eight patients were in a standard risk group and the rest was in a high risk group. The mean follow-up time was 27.8 months and the overall survival was three years. It has been found that the overall survival was affected by the unfavorable prognostic factors such as lar ger (>30 cm') preoperative tumor volume, supratentorial location. bein in hi h risk group and more than fifty days radiotherapy treatment. The preoperative large tumor volume and prolonged radiotherapy duration were determined as unfavorable prognostic factors in our study, that differ from the literature data. Due to the limited number of the patients in this study, these results should be confirmed with additional studies with larger patient groups.