Synthesis of Heterocyclic-Substituted Novel Hydroxysteroids with Regioselective and Stereoselective Reactions


Kolo A. M. , Ipek E., Capan İ. , Servi S.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.55, sa.2, ss.492-497, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Konu: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1002/jhet.3070
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Sayfa Sayıları: ss.492-497

Özet

Polyhydroxy steroids bearing the 3,5,6-trihydroxy pattern were synthesized from different heterocyclic-substituted unsaturated steroid by an easy and simple method with high yields. The endocyclic double bond of thiophene-substituted and quinoline-substituted steroids were converted to the trans-diaxial diol by the regioselective and stereoselective reactions with m-chloroperoxybenzoic acid in the basic medium.