Synthesis of Heterocyclic-Substituted Novel Hydroxysteroids with Regioselective and Stereoselective Reactions

Kolo A. M., Ipek E., Capan İ., Servi S.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.55, no.2, pp.492-497, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1002/jhet.3070
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.492-497
  • Gazi University Affiliated: Yes

Abstract

Polyhydroxy steroids bearing the 3,5,6-trihydroxy pattern were synthesized from different heterocyclic-substituted unsaturated steroid by an easy and simple method with high yields. The endocyclic double bond of thiophene-substituted and quinoline-substituted steroids were converted to the trans-diaxial diol by the regioselective and stereoselective reactions with m-chloroperoxybenzoic acid in the basic medium.