Lipid peroxidation, nitrate and nitrite levels in eclamptic and intrauterine growth retarded pregnancies


PAŞAOĞLU H. , BUKAN N. , Bulduk G., Çelen Ş.

Turkish Journal of Medical Sciences, vol.33, no.2, pp.89-93, 2003 (Journal Indexed in SCI Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 2003
  • Title of Journal : Turkish Journal of Medical Sciences
  • Page Numbers: pp.89-93

Abstract

In this study we investigated nitric oxide metabolites nitrate+nitrite and lipid peroxidation product (malonyldialdehyde: MDA) related to the pathogenesis of eclampsia and intrauterine growth retarded (IUGR) pregnancy. Plasma nitrate+nitrite levels were higher in the eclamptic (31.6 ± 16.7 μmol/L p < 0.001) and IUGR (24.3 ± 9.5 μmol/L p < 0.005) groups than in the control group (18.8 ± 6.9 μmol/L). Plasma MDA levels were higher in the eclamptic group (5.5 ± 2.5 nmol/ml (p > 0.05) but not significantly different in the IUGR (3.4 ± 2.4 nmol/ml p > 0.05) group than control group (3.0 ± 1.3 nmol/ml). In addition, the plasma nitrite+nitrate and MDA levels in the eclamptic group were higher than in the IUGR group (p < 0.05). These variations could play different roles in the pathogenesis of eclampsia and IUGR pregnancy.