Soluble Endoglin Level Increase Occurs Prior to Development of Subclinical Structural Vascular Alterations in Diabetic Adolescents.


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Emeksiz H. C. , BİDECİ A. , Damar C., Derinkuyu B. E. , Celik N., DÖĞER E. , ...More

Journal of clinical research in pediatric endocrinology, vol.8, no.3, pp.313-20, 2016 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.4274/jcrpe.2906
  • Title of Journal : Journal of clinical research in pediatric endocrinology
  • Page Numbers: pp.313-20
  • Keywords: Type 1 diabetes mellitus, subclinical atherosclerosis, soluble endoglin, adolescents, FLOW-MEDIATED DILATION, TGF-BETA RECEPTOR, NITRIC-OXIDE, ASYMMETRIC DIMETHYLARGININE, ENDOTHELIAL DYSFUNCTION, CHILDREN, ATHEROSCLEROSIS, EXPRESSION, MELLITUS, CELLS

Abstract

Objective: Soluble endoglin (S-endoglin) has been implicated as a potential marker of endothelial dysfunction (ED) and was reported to be elevated in diabetic adults, correlating with the severity of diabetic vasculopathy. However, circulating S-endoglin and its association with other markers of ED have not been formerly analyzed in the first decade of diabetes onset in adolescents with type 1 diabetes mellitus (T1DM).