Akademik Veri Yönetim Sistemi
International Journal of Cutaneous Disorders & Medicine , cilt.5, sa.1, ss.1-4, 2024 (Hakemli Dergi)
Kaposi’s sarcoma is a vascular tumor associated with HHV-8. Clinically, there are classical, AIDS-related epidemic, endemic
and iatrogenic types. Local, interventional and systemic treatments are available depending on the type of disease, extent and
severity of lesions. However, there is no consensus on optimal treatments and this causes difficulties in treatment selection.
Topical treatments such as alitretinoin, timolol, imiquimod, silver nitrate application, laser and surgery can be used. In systemic
treatment, chemotherapeutics, immune modulators and antiviral agents can be used. Apart from these, successful results have
been reported with treatments such as mTOR inhibitors, immune checkpoint inhibitors, PD-L1 inhibitors. In addition, treatments
targeting enzymes such as methyltransferase, RNase and nitric oxide synthase are promising.