Effect of homocysteine on bone mineral density of rats

Soyupek F., Cerci S., Yidiz S., Yildiz M., Gurnus B. A.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.118, no.3, pp.255-259, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 118 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1007/s12011-007-0034-8
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.255-259
  • Keywords: homocysteine, bone, mineral density, rats, methionine, FOLATE
  • Gazi University Affiliated: No


The relationship between plasma levels of homocysteine (Hcy) and femur bone mineral density (BMD) was studied in Wistar rats. After 8 weeks of treatment with 0.5 and 1.0 g kg(-1) day(-1) L-methionine the mean plasma levels of Hey were 7.67+/-1.25 and 61.2+/-11.4 mu mol/l, respectively. Only rats treated with the higher dose had Hey levels significantly higher than those of controls, 6.38+/-0.90 mu mol/l (p<0.001). Dual Energy X-ray Absotptiometry was used to measure the BMD, which was significantly lower only in the animals with the highest plasma levels of Hey (p<0.001). This led us to conclude that increased levels of Hcy are associated with risk of decreased BMD.