Evidence-based medicine, established on prospective studies and related algorithms is living its golden age in recent years. Within the last few decades, medical knowledge has been systematically produced, categorized, and spread in a way never seen before. One of the most important factors in realizing this situation is the expansion of the communication facilities. The area of the management of head and neck cancers was also affected by these advances, and studies with high-level evidence became the mainstay in the determination of the management strategies. However, probably almost all of these studies are about non-surgical modalities, and studies with high-level evidence regarding the surgical treatment of head and neck cancers are scarce. In this paper, important studies on head and neck cancers and their results will be reviewed.