Unconfined compressive strength (UCS) of high plasticity clayey soil mixed with 5 and 10 % of Portland cement and four chemical agents such as sodium hexametaphosphate, aluminum sulfate, sodium carbonate, and sodium silicate with 0, 5, 10, and 20% concentrations was comparatively evaluated. The individual and combined effects of the cement and chemical agents on the UCS of the soil mixture were investigated The strength of the soil-cement mixture generally increases with increasing the cement content. However, if the chemical agent is added to the mixture, the strength of the cement-chemical agent-soil mixture tends to vary depending on the type and the amount of the chemical agent. At low concentrations of 5% of aluminum sulfate and 5% and 10% of sodium carbonate, the average UCS of the cement-chemical agent-soil mixture slightly increased compared to pure clay due to increasing the flocculation of the clay in the mixture. However, at high concentrations (20%) of all chemical agents, the UCS significantly decreased compared to the pure clay and clay-cement mixtures. In the case of high cement content, the rate of UCS reduction is the highest among all cement-chemical agent-soil mixtures, which is more than three times higher in comparison to the soil-chemical agent mixtures without cement. Therefore, in the mixture with high cement (> 10%), the reduction of the USC is very sensitive when the chemical agent is added.