Antiprotozoal assessment and phenolic acid profiling of five Fumaria (fumitory) species

ERDOĞAN ORHAN İ., ÖZTÜRK N., Sener B.

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, cilt.8, sa.4, ss.283-286, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/s1995-7645(14)60331-x
  • Dergi Adı: ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.283-286
  • Anahtar Kelimeler: Fumaria, Fumitory, Antiprotozoal, Malaria, Trypanosomiasis, Phenolic acid, MEDICINAL-PLANTS, PLASMODIUM-FALCIPARUM, TRYPANOSOMA-BRUCEI, IN-VITRO, ALKALOIDS, GAMBIENSE, RHODESIENSE, ANTIOXIDANT
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: To explore some Fumaria species which were recorded to be traditionally used against malaria and other protozoal diseases. Methods: Consequently, in the current study. antiprotozoal effect of the ethanol extracts obtained from five Fumaria species (Fumaria densiflora, Fumaria cilicica, Fumaria rostellata, Fumaria kralikii, and Fun:aria parviflora) was investigated against the parasites; Plasmodium falciparum (malaria) and Tryanosoma bruceirhodesiense (human African trypanosomiasis) at 0.81 and 4.85 mu g/mL concentrations. Results: Among them, Fumaria densiflora extract exerted the highest antiplasmodial (93.80%) and antitrypanasomal effect (55.40%). while the ethanol extracts of Fumaria kralikii (43.45%) and Fumaria rostellata (41.65%) showed moderate activity against Plasmodium falciparum. Besides, phenolic acid contents of the extracts were analyzed using high performance liquid chromatography (HPLC) and trans-cinnamic (4.32 mg/g) and caffeic (3.71 mg/g) acids were found to be the dominant phenolic acids in Fumaria densiflora. Conclusions: According to our results. Fumaria densiflora deserve further study for its promising antiprotozoal activity.