Akademik Veri Yönetim Sistemi
JOURNAL OF POLYTECHNIC-POLITEKNIK DERGISI, 2024 (ESCI)
One important area of research in tissue engineering is scaffold design. Before isolated cells are transplanted, a scaffold is a threedimensional scaffolding that offers temporary support for the development of new tissue. The goal of scaffolds used in tissue engineering is for cells to colonize them. Scaffolds must deliver the required chemical and physical signals to guarantee adequate tissue growth. The most straightforward of all nerve guide conduits (NGC) designs is the hollow and non-porous design, which consists of a hollow tube composed of either natural or artificial polymers. Negative aspects due to its non-porous nature, the capacity for nerve regeneration will be impacted by the permeability of growth agents and nutrients into and out of the channel. Mass cannot be transferred across the membrane since it is non-porous. This permeability issue has led to the development of porous NGCs. The porous NGC designs based on Triply Periodic Minimal Surfaces (TPMS), which are produced additively utilizing photopolymer resin material and photopolymerization technique, are examined in this work. Three distinct NGCs in all, two of which have pores with pore sizes between 150 and 350 mu m and porosity greater than 60%, were taken into consideration. This work represents one of the first to report on the 3D printing of NGCs based on TPMS utilizing photopolymer resin. Our results suggest that TPMS-based structures can potentially be adopted to fabricate porous structures suitable for mass transfer required for nerve regeneration.