The DNA methylation drift of the atherosclerotic aorta increases with lesion progression

Del Pilar Valencia-Morales M., Zaina S., Heyn H., Javier Carmona F., Varol N., Sayols S., ...Daha Fazla

BMC MEDICAL GENOMICS, cilt.8, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1186/s12920-015-0085-1
  • Dergi Adı: BMC MEDICAL GENOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Atherosclerosis, Aorta, DNA methylation, Genome-wide analysis, GENE-EXPRESSION, GROWTH-FACTOR, ACTIVATION, MECHANISMS, REGULATOR, PHENOTYPE, DYNAMICS, DISEASE, GAMMA, MICE
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Atherosclerosis severity-independent alterations in DNA methylation, a reversible and highly regulated DNA modification, have been detected in aortic atheromas, thus supporting the hypothesis that epigenetic mechanisms participate in the pathogenesis of atherosclerosis. One yet unaddressed issue is whether the progression of atherosclerosis is associated with an increase in DNA methylation drift in the vascular tissue. The purpose of the study was to identify CpG methylation profiles that vary with the progression of atherosclerosis in the human aorta.