Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: A double-blind randomized trial


Ozturk B., Egehan I., Atavci S., Kitapci M.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol.58, no.1, pp.213-219, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1016/s0360-3016(03)01444-5
  • Title of Journal : INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
  • Page Numbers: pp.213-219
  • Keywords: pentoxifylline, lung, toxicity, radiotherapy, LENT score, DOSE-VOLUME HISTOGRAM, STAGE-II, PNEUMONITIS, THERAPY, IRRADIATION, PERFUSION, INJURY

Abstract

Purpose: Pentoxifylline (Ptx) is thought to be helpful in preventing radiotoxicity by inhibiting platelet aggregation and tumor necrosis factor. We assessed whether prophylactic use of Ptx could prevent early and late normal lung tissue damage due to radiotherapy in a double-blind, randomized trial.