STUDIES ON IN VITRO ANTIMYCOBACTERIAL ACTIVITIES OF SOME 2-SUBSTITUTEDIMIDAZO[4,5-b] AND [4,5-c]PYRIDINE DERIVATIVES

ÖZÇELİK A. B., ÜLGER M., ASLAN G., EMEKDAŞ G., Ozden T.

REVUE ROUMAINE DE CHIMIE, cilt.59, sa.1, ss.5-8, 2014 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 1
  • Basım Tarihi: 2014
  • Dergi Adı: REVUE ROUMAINE DE CHIMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.5-8
  • Anahtar Kelimeler: imidazo[4,5-b]pyridine, imidazo[4,5-c]pyridine, antimycobacterial activity, POTENTIAL TUBERCULOSTATIC ACTIVITY, PLATELET-ACTIVATING-FACTOR, C-VIRUS ACTIVITY, ANTITUBERCULOTIC ACTIVITY, ANTIPROLIFERATIVE ACTIVITY, INHIBITORS, IMIDAZO<4,5-C>PYRIDINES, IMIDAZO<4,5-B>PYRIDINES, ISOTHIOCYANATES, IMIDAZOPYRIDINE
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study, 2-substitutedimidazo[4,5-b]pyridine and 2-substitutedimidazo[4,5-c]pyridine which have -CH2OH, -CH2Cl, -CH3 or -C2H5 groups in positions 2 have been synthesized and tested for their in vitro antimycobacterial activity against M. tuberculosis H37Rv strains. The compounds were synthesized by previously reported methods. 2-Chloromethylimidazo[4,5-b]pyridine and 2-methylimidazo[4,5-c]pyridine were found to be more active than the other compounds tested.