Superoxide in the pulmonary circulation


Demiryurek A., Wadsworth R.

PHARMACOLOGY & THERAPEUTICS, cilt.84, sa.3, ss.355-365, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 84 Konu: 3
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0163-7258(99)00041-8
  • Dergi Adı: PHARMACOLOGY & THERAPEUTICS
  • Sayfa Sayıları: ss.355-365

Özet

Superoxide formation in pulmonary tissue is modulated by cytokines, PO2, shear force, and disease states, and can be stimulated by drugs. Superoxide has diverse actions on pulmonary cells, including smooth muscle contraction, interaction with redox enzymes, cell pro liferation, and gene transcription. In the lungs, there is an impressive array of specific defence mechanisms that destroy superoxide, especially superoxide dismutase (SOD) and metallothionein. Superoxide formation is increased in hyperoxia (e.g., oxygen therapy); however, superoxide-forming enzymes also can be up-regulated in hypoxia. Superoxide has been implicated in acute respiratory distress syndrome, lung ischaemia-reperfusion injury, and lung transplantation. Novel approaches to therapy have been explored, including SOD gene therapy and SOD targeting to the lung. In the future, new drugs interacting with superoxide may provide significant advances in the treatment of lung diseases. (C) 1999 Elsevier Science Inc, All rights reserved.