The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome

AYYILDIZ F., YILDIRAN H., AFANDIYEVA N., GÜLBAHAR Ö., KÖKTÜRK O.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.5, ss.2524-2533, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/sag-2101-83
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.2524-2533
  • Anahtar Kelimeler: Vitamin D supplementation, obstructive sleep apnea, biochemical parameters, inflammation, POSITIVE AIRWAY PRESSURE, PRACTICE PARAMETERS, ASSOCIATION, CPAP, SUPPLEMENTATION, METABOLISM, GUIDELINE, SEVERITY, MEDICINE, MARKERS
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/aim: The aim of this study was to investigate the effect of vitamin D on the disease prognosis and biochemical parameters in patients with mild obstructive sleep apnea syndrome (OSAS). Materials and methods: Nineteen adult male individuals (18-65 years) who were diagnosed with mild OSAS after polysomnography and had low vitamin D levels were included in the study. Each week, patients took 50.000 IU Vitamin D3 supplementation for 8 weeks. Polysomnography, biochemical parameters FBG (fasting blood glucose), lipid profile (TG, TC, LDL-C, HDL-C, VLDL-C), calcium, phosphorus, parathormone, calcitonin, serum 25(OH)D, insulin, CRP, TNF-alpha, IL-6, and IL-10 of patients were evaluated at the beginning of study and at the end of the study. All assessments, including polysomnography, were repeated after 8 weeks. Results: Serum vitamin D levels were initially 19.5 +/- 5.01 ng/mL and increased to 41.8 +/- 10.51 ng/mL (p < 0.001) at the end of the study. FBG, TC and HOMA-IR of the patients were significantly decreased (p < 0.05). CRP, TNF-alpha, IL-6, and IL-10 levels were also correlated with serum vitamin D levels (p < 0.05). There was a significant decrease in number of obstructive apneas, apneas and hypopneas, apnea index, hypopnea index, and apnea hypopnea index of the patients (p < 0.05). Conclusion: As a result, it is thought that vitamin D supplementation may have a positive effect on the disease prognosis of mild OSAS.