Tobacco-Induced Neuronal Degeneration via Cotinine in Rats Subjected to Experimental Spinal Cord Injury

Dalgic, Ali; Okay, Onder; Helvacioglu, Fatma; Daglioglu, Ergun; Akdag, Rifat; TAKE KAPLANOĞLU, GÜLNUR; Belen, Deniz

doi:10.1055/s-0033-1337607

Tobacco-Induced Neuronal Degeneration via Cotinine in Rats Subjected to Experimental Spinal Cord Injury

Atıf İçin Kopyala

Dalgic A., Okay O., Helvacioglu F., Daglioglu E., Akdag R., TAKE KAPLANOĞLU G., ...Daha Fazla

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY, cilt.74, sa.3, ss.136-145, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 74 Sayı: 3
Basım Tarihi: 2013
Doi Numarası: 10.1055/s-0033-1337607
Dergi Adı: JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.136-145
Gazi Üniversitesi Adresli: Evet

Özet

Objectives Cigarette smoke contains over 4000 chemicals including well-characterized toxicants and carcinogens, among which is cotinine. Cotinine is the principal metabolite of nicotine that has adverse affects on the microcirculation via vasoconstriction, hypoxia and the wound-healing cascade. Its impact on spinal cord injury (SCI) has not been investigated yet. The aim of the present study is to investigate the cotinine effect on SCI.