Tobacco-Induced Neuronal Degeneration via Cotinine in Rats Subjected to Experimental Spinal Cord Injury


Dalgic A., Okay O., Helvacioglu F., Daglioglu E., Akdag R., TAKE KAPLANOĞLU G. , ...Daha Fazla

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY, cilt.74, sa.3, ss.136-145, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 74 Konu: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1055/s-0033-1337607
  • Dergi Adı: JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
  • Sayfa Sayıları: ss.136-145

Özet

Objectives Cigarette smoke contains over 4000 chemicals including well-characterized toxicants and carcinogens, among which is cotinine. Cotinine is the principal metabolite of nicotine that has adverse affects on the microcirculation via vasoconstriction, hypoxia and the wound-healing cascade. Its impact on spinal cord injury (SCI) has not been investigated yet. The aim of the present study is to investigate the cotinine effect on SCI.