Nitroglycerin challenge induces lateralized headache in nasociliary nerve-ligated rats: implications for chronic migraine

Akcali D. T., Belen A. D., Babacan A., Bolay H. B.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.47, sa.2, ss.681-688, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3906/sag-1602-86
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.681-688
  • Anahtar Kelimeler: Rat, nitroglycerin, chronic migraine, headache, nasociliary nerve ligation, c-fos, ELEVATED PLUS-MAZE, VON FREY MONOFILAMENTS, TRIGEMINAL NEURONS, FACIAL STIMULATION, MODEL, ALLODYNIA, RESPONSES, PAIN, ANXIETY, INJURY
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/aim: Chronic migraine is a common debilitating disease with limited treatment options. We aimed to develop a novel model for chronic migraine by ligating the nasociliary nerve (NCL) and administering nitroglycerin (NTG) to exacerbate acute headache attacks.