Formulation of ELF magnetic fields' effects on malondialdehyde level and myeloperoxidase activity in kidney using genetic programming

Tohumoglu G., Canseven A. G., Cevik A., Seyhan N.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, cilt.86, sa.1, ss.1-9, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86 Sayı: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.cmpb.2006.12.006
  • Dergi Adı: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-9
  • Anahtar Kelimeler: genetic programming, MDA level, MPO activity, ELF magnetic fields, ELECTROMAGNETIC-FIELDS, LIPID-PEROXIDATION, ELECTRIC-FIELD, BRAIN, EXPOSURE, NEUTROPHILS, TISSUES, DAMAGE, LIVER
  • Gazi Üniversitesi Adresli: Hayır

Özet

In vivo exposure effects of electromagnetic fields (EMFs) on various tissues of experiment animals have been investigated. In this sense, modeling and formulation of these biological effects have been of significant importance. In this study extremely low frequency (ELF) EMFs effects on malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in kidney of guinea pigs exposed to 50 Hz magnetic fields of 1 mT, 2 mT and 3 mT have been presented. It has been planned to determine whether genetic programming (GP) is appropriate to analyze and formulate these biological effects. Consequently, it has been observed that GP can be effectively used to model MDA level and MPO activity. The performances of prediction of the proposed GP formulation versus actual experimental values are found to be quite satisfactory in terms of standard deviation and correlation coefficient. It is concluded that the GP application serves to form a database for the researchers in this field, without exposing tissues to EMF and without using too many guinea pigs. (c) 2006 Elsevier Ireland Ltd. All rights reserved.