A Multicenter Clinical Analysis of Cleft Lip and Palate: Clinical Features, Parental Background, and Associated Anomalies

ÜSTÜN, GALİP; KÜÇÜK, KUTLUHAN; Irmak, Yusuf; Calik, Bartu; Mete, Seyhmus; Aksoyler, Dicle; KESİKTAŞ, EROL; TABAKAN, İBRAHİM; TENEKECİ, GÖKTEKİN; ÜNAL, ŞAKİR; Dogruyol, Ahmet; Demir, Ahmet; GÜRAY, ŞEYDA; Uruc, Murat; Cicek, Cagla; Filinte, Gaye; KOYUNCU, AHMET; DADACI, MEHMET; BİÇER, AHMET; GÜRLER, TAHİR; Ceylan, Ender; AYDIN, OSMAN; DORUK, MERT; ŞİBAR, SERHAT; DAĞ, OSMAN; KAPLAN, GÜVEN; KARA, MURAT; ÇALIŞ, MERT; Ozgur, Figen

doi:10.1177/10556656261464302

A Multicenter Clinical Analysis of Cleft Lip and Palate: Clinical Features, Parental Background, and Associated Anomalies

ÜSTÜN G. G., KÜÇÜK K. Y., Irmak Y., Calik B. Y., Mete S., Aksoyler D., ...Daha Fazla

CLEFT PALATE CRANIOFACIAL JOURNAL, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Basım Tarihi: 2026
Doi Numarası: 10.1177/10556656261464302
Dergi Adı: CLEFT PALATE CRANIOFACIAL JOURNAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, Educational research abstracts (ERA), EMBASE, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
Gazi Üniversitesi Adresli: Evet

Özet

Objective To provide a contemporary, multicenter clinical and epidemiologic overview of cleft lip and/or palate (CL/P) and to analyze associations with phenotype, Veau classification, parental characteristics, and perinatal factors.Methods This retrospective multicenter study included 2488 patients with CL/P treated between 2018 and 2022 at 11 tertiary referral centers in T & uuml;rkiye. Demographic data, cleft phenotype, Veau classification, syndromic status, associated congenital anomalies, parental age, consanguinity, antenatal follow-up, teratogenic exposure, and perinatal complications were analyzed using descriptive and comparative statistics.Results A total of 2488 patients with CL/P were included. Combined cleft lip and palate (CLP) was the most common phenotype (44.8%), followed by cleft palate (CP only-34.3%) and cleft lip (CL only-20.9%). Syndromic or sequential conditions were present in 5.7% and associated congenital anomalies in 17.0%, most frequently cardiovascular defects (7.0%). Consanguinity was reported in 21.9% of families. Compared with CL and CLP, CP was characterized by female predominance and significantly higher rates of syndromic involvement, associated anomalies, and perinatal complications. These associations remained significant in multivariable analysis. Among patients with CP, incomplete CP (Veau I-II) was independently associated with female sex, syndromic status, and perinatal complications. Higher maternal and paternal ages were associated with nonpreterm perinatal complications but not with preterm birth.Conclusions CP only represents a distinct clinical and epidemiologic entity with a higher syndromic and comorbidity burden. This large multicenter cohort provides updated reference data for contemporary cleft research and supports subtype-specific evaluation and multidisciplinary management.Level of evidence Level III-Prognostic/Etiologic Evidence (Retrospective Cohort Study).