The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E(2) and leukotriene C-4 levels after mesenteric ischemia-reperfusion injury

Sare, MUSTAFA; Bozkurt, S; Onuk, E; Oguz, M; Gurel, M; Ercan, S

doi:10.1016/s0952-3278(96)90120-9

The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E(2) and leukotriene C-4 levels after mesenteric ischemia-reperfusion injury

Atıf İçin Kopyala

Sare M., Bozkurt S., Onuk E., Oguz M., Gurel M., Ercan S.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.55, sa.6, ss.379-383, 1996 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 55 Sayı: 6
Basım Tarihi: 1996
Doi Numarası: 10.1016/s0952-3278(96)90120-9
Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.379-383
Gazi Üniversitesi Adresli: Hayır

Özet

In this study, the changes of arachidonic acid metabolites after an ischemia-reperfusion (I/R) period are investigated. The cyclooxygenase and lipoxygenase metabolites were found to be significantly increased after a 45 min period of ischemia followed by 5 min of reperfusion. Prostaglandin E(2) (PGE(2))- and leukotriene C-4 (LTC(4))-like activities did not change in the ischemic period, but they both increased after reperfusion. A cyclooxygenase inhibitor indomethacin and lipoxygenase inhibitor nordehydroguaretic acid (NDGA) decreased PGE(2)- and LTC(4)-like activities, respectively, while allopurinol and superoxide dismutase (SOD) decreased both activities.