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Albayrak M., Konyssova U., Kaya Z., Gursel T., Guntekin S., Perçin F. E., ...More
Cancer chemotherapy and pharmacology, vol.68, no.5, pp.1155-9, 2011 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
68
Issue:
5
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Publication Date:
2011
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Doi Number:
10.1007/s00280-011-1599-7
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Journal Name:
Cancer chemotherapy and pharmacology
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.1155-9
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Keywords:
Thiopurine methyltransferase polymorphisms, Mercaptopurine, Children, Leukemia, S-METHYLTRANSFERASE, GENETIC POLYMORPHISMS, CAUCASIAN POPULATION, TPMT GENOTYPE, ALLELES, AZATHIOPRINE, THERAPY, PHARMACOGENETICS, INTOLERANCE
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Gazi University Affiliated:
Yes
Abstract
Thiopurine methyltransferase (TPMT) enzyme is involved in the metabolism of 6-mercaptopurine (6-MP), a key component of acute lymphoblastic leukemia (ALL) treatment protocols in children. The aims of this study were to investigate the frequency of common genetic polymorphisms associated with low TPMT activity and correlations of polymorphic variants with 6-MP tolerance in a group of Turkish children with ALL.