Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia


Albayrak M., Konyssova U., Kaya Z., Gursel T., Guntekin S., PERÇİN F. E. , ...Daha Fazla

CANCER CHEMOTHERAPY AND PHARMACOLOGY, cilt.68, ss.1155-1159, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 68 Konu: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00280-011-1599-7
  • Dergi Adı: CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Sayfa Sayıları: ss.1155-1159

Özet

Thiopurine methyltransferase (TPMT) enzyme is involved in the metabolism of 6-mercaptopurine (6-MP), a key component of acute lymphoblastic leukemia (ALL) treatment protocols in children. The aims of this study were to investigate the frequency of common genetic polymorphisms associated with low TPMT activity and correlations of polymorphic variants with 6-MP tolerance in a group of Turkish children with ALL.