Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia.

Albayrak M., Konyssova U., Kaya Z., Gursel T., Guntekin S., Perçin F. E., ...More

Cancer chemotherapy and pharmacology, vol.68, no.5, pp.1155-9, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1007/s00280-011-1599-7
  • Journal Name: Cancer chemotherapy and pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1155-9
  • Keywords: Thiopurine methyltransferase polymorphisms, Mercaptopurine, Children, Leukemia, S-METHYLTRANSFERASE, GENETIC POLYMORPHISMS, CAUCASIAN POPULATION, TPMT GENOTYPE, ALLELES, AZATHIOPRINE, THERAPY, PHARMACOGENETICS, INTOLERANCE
  • Gazi University Affiliated: Yes

Abstract

Thiopurine methyltransferase (TPMT) enzyme is involved in the metabolism of 6-mercaptopurine (6-MP), a key component of acute lymphoblastic leukemia (ALL) treatment protocols in children. The aims of this study were to investigate the frequency of common genetic polymorphisms associated with low TPMT activity and correlations of polymorphic variants with 6-MP tolerance in a group of Turkish children with ALL.